Human hands can only tolerate being clapped together so many times. There’s actually a finite upper limit. After that, the body tries to pad and protect them by releasing helium from special glands in the wrists. The hands inflate in an effort to prevent further damage.
This is the whole reason that open air concerts and theatrical performances for the elderly have been banned in most countries. The expense is just to high when over-exuberant audiences unwittingly applaud themselves into becoming airborne in droves.